THE REVACCINATION BILL, 1904.

Dmd065755 1891..1904

The cytochrome P450 2C19 (CYP2C19) enzyme plays an important role in the metabolism of many commonly used drugs. Relatively little is known about CYP2C19 inhibitors, including compounds of natural origin, which could inhibit CYP2C19, potentially causing clinically relevant metabolism-based drug interactions. We evaluated a series (N = 49) of structurally related plant isoquinoline alkaloids for...

Revaccination and Duration of Protection

Pneumococcal polysaccharide vaccine induces an initial rise in ELISA antibody levels, which then decline over time and in older adults antibody levels measured 4 to 7 years post-vaccination tend to approximate pre-vaccination baseline levels (1-5). The clinical significance of this decline is not well defined, as immune correlates of protection for pneumococcal vaccine in adults have not been e...

Op-scan130187 1904..1913

Silvio Ionta,* Roberto Martuzzi, Roy Salomon, and Olaf Blanke Center for Neuroprosthetics, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland; Laboratory of Cognitive Neuroscience, Brain-Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland; and Department of Neurology, University Ho...

Ernst Mayr: 1904 – 2005

One Long Argument, the title of one of Ernst Mayr's later popular books on evolution, in many ways sums up the core of his intellectual life. Mayr, a leading evolutionary biologist over many years of the past century, who died aged 100 last month, was an explorer, naturalist, ornithologist, philosopher, historian of science and Harvard academic. Like Darwin, he was studying medicine when his fo...

The Drug Control Bill